2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-135329S
    (1R,3S-)Solifenacin-d5 hydrochloride 1217810-85-9 98%
    (1R,3S-)Solifenacin-d5 hydrochloride is the deuterium labeled Solifenacin hydrochloride. Solifenacin D5 hydrochloride is a deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride is a muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
    (1R,3S-)Solifenacin-d5 hydrochloride
  • HY-135478A
    LY393615 free base 774528-12-0 98%
    LY393615 (NCC1048) free base is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 free base has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research.
    LY393615 free base
  • HY-135556A
    Norfluoxetine oxalate 107674-50-0 98%
    Norfluoxetine oxalate is an active metabolite of Fluoxetine (HY-B0102). Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
    Norfluoxetine oxalate
  • HY-13575S1
    Blonanserin-d5 1346599-86-7 98%
    Blonanserin-d5 (AD-5423-d5) is a deuterium labeled Blonanserin (HY-13575). Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic.
    Blonanserin-d5
  • HY-136299R
    Sepimostat (Standard) 103926-64-3
    Sepimostat (Standard) is the analytical standard of Sepimostat. This product is intended for research and analytical applications. Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 μM.
    Sepimostat (Standard)
  • HY-136520B
    Xanthoanthrafil 1020251-53-9 98%
    Xanthoanthrafil is a potent phosphodiesterase-5 (PDE5) inhibitor, with an IC50 of 3.95 ng/mL. Xanthoanthrafil can be used for the research of erectile dysfunction.
    Xanthoanthrafil
  • HY-136610R
    Chlorpyrifos-oxon (Standard) 5598-15-2 98%
    Chlorpyrifos-oxon (Standard) is the analytical standard of Chlorpyrifos-oxon. This product is intended for research and analytical applications. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function.
    Chlorpyrifos-oxon (Standard)
  • HY-137311A
    (S)-Albuterol 34271-50-6 98%
    (S)-Albuterol is a muscarinic receptor and phospholipase C activator. (S)-Albuterol increases intracellular free calcium in airway smooth muscle.
    (S)-Albuterol
  • HY-137532S
    7-Hydroxy Quetiapine-d8 1185098-57-0 98%
    7-Hydroxy Quetiapine-d8 is the deuterium labeled 7-Hydroxyquetiapine. 7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine.
    7-Hydroxy Quetiapine-d8
  • HY-138257A
    (R)-Indeloxazine benzenesulfonate 1623762-83-3 98%
    (R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor, with IC50 values of 0.35 μM and 3.3 μM, respectively. (R)-Indeloxazine benzenesulfonate (AS1069562) possesses curative-like analgesic effect. (R)-Indeloxazine benzenesulfonate (AS1069562) might improve nerve function impairment via the amelioration of neurotrophic support.
    (R)-Indeloxazine benzenesulfonate
  • HY-139347A
    Mazisotine tartrate 2919211-45-1 98%
    Mazisotine (CNTX-0290) tartrate is an orally active, non-opioid somatostatin receptor 4 (SSTR4) agonist with an EC50 of 4.7 nM. Mazisotine tartrate exerts significant analgesic effects in various nociceptive (inflammatory, osteoarthritic) and neuropathic pain models. Mazisotine tartrate can be used for pain research.
    Mazisotine tartrate
  • HY-141554A
    (2S,3S,11bR)-Dihydrotetrabenazine 862377-27-3 98%
    (2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR)-Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR)-Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders.
    (2S,3S,11bR)-Dihydrotetrabenazine
  • HY-14258AS
    Escitalopram-d6 oxalate 1217733-09-9 98%
    Escitalopram-d6 (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression.
    Escitalopram-d6 oxalate
  • HY-14325BR
    L-745870 hydrochloride (Standard) 1173023-36-3
    L-745870 (hydrochloride) (Standard) is the analytical standard of L-745870 (hydrochloride). This product is intended for research and analytical applications. L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors.
    L-745870 hydrochloride (Standard)
  • HY-14336AR
    SB 271046 Hydrochloride (Standard) 209481-24-3 98%
    SB 271046 (Hydrochloride) (Standard) is the analytical standard of SB 271046 (Hydrochloride). This product is intended for research and analytical applications. SB 271046 Hydrochloride (SB 271046A) is a potent, selective, orally active and BBB-permeable 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM).
    SB 271046 Hydrochloride (Standard)
  • HY-14338AR
    Idalopirdine hydrochloride (Standard) 467458-02-2 98%
    Idalopirdine (hydrochloride) (Standard) is the analytical standard of Idalopirdine (hydrochloride). This product is intended for research and analytical applications. Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders.
    Idalopirdine hydrochloride (Standard)
  • HY-14407AR
    Fosaprepitant dimeglumine (Standard) 265121-04-8
    Fosaprepitant (dimeglumine) (Standard) is the analytical standard of Fosaprepitant (dimeglumine). This product is intended for research and analytical applications. Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).
    Fosaprepitant dimeglumine (Standard)
  • HY-14538S2
    Haloperidol-d4 N-Oxide 1246815-56-4 98%
    Haloperidol-d4 N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
    Haloperidol-d4 N-Oxide
  • HY-14541S1
    Olanzapine-d4 1252611-62-3 98%
    Olanzapine-d4 (LY170053-d4) is deuterium-labeled Olanzapine (HY-14541).
    Olanzapine-d4
  • HY-145482R
    W36017 (Standard) 21236-54-4
    8-Hydroxyquinoline (hemisulfate) (Standard) is the analytical standard of 8-Hydroxyquinoline (hemisulfate). This product is intended for research and analytical applications. 8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.
    W36017 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity